Key result
Warming to 41C vs 37C increases calf cardiac vein sensitivity to contractile agents.
Why the study?
The effects of warming on the response to various contractile agents in calf cardiac vein and the role of nitric oxide were unclear.
Warming increases the sensitivity of calf cardiac veins to contractile agents through a nitric oxide-independent mechanism.
Answers are grounded in this paper and cite their sources.
Warming augments isolated vein contractility; hypothesis-generating for temperature effects on cardiac venous tone in vivo.
The effects of warming on the response to various contractile agents of calf cardiac vein were studied using 2.5-mm long cylindrical segments. Concentration-response curves for carbachol (10(-9)-3 x 10(-4) m), 5-hydroxytryptamine (5-HT; 10(-8)-3 x 10(-3)), potassium chloride (KCl; 10(-4)-5 x 10(-2) m) and calcium chloride (CaCl2; 10(-4)-10(-2)) were isometrically recorded at 37 and 41 degrees C (warming). During warming the sensitivity, but not the maximal response, of carbachol 5-HT, KCl, and CaCl2 was significantly higher than at 37 degrees C. Warming to 41 degrees C after treatment with NG-nitro-L arginine methyl esther (10(-5) m) did not modify the effect of warming. These results suggest that nitric oxide seems to have no role in the warming-induced responses in calf cardiac vein.
No takes yet. Share an insight, caveat, or question.
Atalık et al. (2003) studied this question. Warming to 41 degrees C vs. 37 degrees C was evaluated on Sensitivity and maximal response to contractile agents (carbachol, 5-HT, KCl, CaCl2). Warming to 41 degrees C significantly increased the sensitivity of calf cardiac vein to contractile agents compared to 37 degrees C, an effect not modified by nitric oxide inhibition.
Synapse has enriched 10 related papers. Consider them for comparative context: