Effect of Vitamin D Supplement on Hormonal Imbalance and Insulin Resistance in PCOS Patients with Deficiency in Misurata, Libya

Introduction: Polycystic ovary syndrome (PCOS) is a frequent hormonal problem in women of childbearing age and can affect fertility and health. This trial examined whether supplementing Vitamin D to increase its levels would affect hormone level measurements and metabolism in Vitamin D-deficient women with PCOS. Materials and Methods: Fifty women with PCOS participated. Half were given Vitamin D injections, and the other half were not (control). The researchers measured hormones such as luteinising hormone (LH), follicle-stimulating hormone (FSH), testosterone and Vitamin D, as well as insulin resistance, before and after the treatment. Results: The Vitamin D group had improved insulin sensitivity and hormone level changes. There were significant differences in LH, FSH and testosterone. Vitamin D levels were significantly higher in the treatment group. The severity of insulin resistance at the beginning of the treatment helped predict who would benefit from the treatment. Conclusion: Vitamin D supplementation was associated with improved hormone levels and insulin sensitivity in Vitamin D-deficient women with PCOS. This implies that Vitamin D may be a potential treatment for PCOS. Further studies are required to validate these results and determine the optimal dose and duration of Vitamin D treatment in women with PCOS.