conditions, transfection efficiency was evaluated at the various conditions (Optison, 10-50%; USE, 0,5-8 min.)using FITC expression in the allografts as an indicator.We then evaluated the therapeutic effect of NFkB-decoy on renal allografts in a rat model (Wistar-Lewis).RESULTS: We discovered optimal conditions for ultrasound-Optisonmediated procedure (Optison, 10%; US, 1min), which provide successful transfection of NFkB-decoy into allografts.The treatment significantly prolonged animal survival (14.2 vs. 7.5 days, n=lO, p
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A 2003 study studied this question.