Key result
Bromopride decreases anastomotic tensile strength and hydroxyproline concentration versus saline in septic rats.
Why the study?
The effects of bromopride on the healing of left colonic anastomoses in the presence of abdominal sepsis were not well understood.
Does bromopride affect the healing of left colonic anastomoses in rats with induced abdominal sepsis?
Does bromopride affect the healing of left colonic anastomoses in rats with induced abdominal sepsis?
p-value: p=0.02
In a rat model of abdominal sepsis, bromopride administration impaired early healing of left colonic anastomoses, as evidenced by decreased tensile strength and hydroxyproline concentration at 3 days.
Bromopride may impair early anastomotic healing in septic rats; hypothesis-generating and should not yet change clinical practice.
PURPOSE: To evaluate the effects of bromopride on the healing of left colonic anastomoses in rats with induced abdominal sepsis. METHODS: Forty rats were divided into two groups to receive either bromopride (experimental group- E) or saline (control group- C). Each group was divided into subgroups of ten animals each to be euthanized on third (E3 and C3) or seventh day (E7 and C7) after surgery. Sepsis was induced by cecal ligation and puncture. The rats underwent segmental left colon resection and end-to-end anastomosis. Adhesion formation, tensile strength and hydroxyproline concentration were assessed. Histomorphometry of collagen and histopathological analysis were also performed. RESULTS: On postoperative third day, anastomoses in bromopride-treated animals showed lower tensile strength (p=0.02) and greater reduction in hydroxyproline concentration (p=0.04) than in control animals. There was no statistical difference in these parameters on seventh day, and the remaining parameters were similar across subgroups. Collagen content was also similar across subgroups. CONCLUSION: In the presence of abdominal sepsis, the administration of bromopride was associated with decreased tensile strength and hydroxyproline concentration in left colonic anastomoses in rats three days after surgery.
No takes yet. Share an insight, caveat, or question.
Silva et al. (2012) studied Induced abdominal sepsis and left colonic anastomoses (n=40). Bromopride vs. Saline was evaluated on Healing of left colonic anastomoses (tensile strength and hydroxyproline concentration) (p=0.02). In rats with induced abdominal sepsis, bromopride administration decreased anastomotic tensile strength (p=0.02) and hydroxyproline concentration (p=0.04) at 3 days post-surgery compared to saline.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: