The Motherisk Program, Division of Clinical Pharmacology and Toxicology, the Departments of Pediatrics and Population Health Sciences, and the Research Institute, Hospital for Sick Children, and the Departments of Pediatrics, Pharmacology, and Medicine, University of Toronto, Toronto, Ontario, Canada N. Engl. J. Med., 338: 1128-1137, 1998
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Koren et al. (1999) studied this question.