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January 1, 2016RSC Advances

An ultra high performance liquid chromatography-tandem mass spectrometry method for the quantification of linagliptin in human plasma

Nagaraj Kumar Nannapaneni Sunil Jalalpure Rajendraprasad Muppavarapu Sunil Kumar Sirigiri

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Abstract

First report of a quality linagliptin assay in human plasma using UHPLC-ESI-MS/MS.

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Nannapaneni et al. (2016) studied this question.

synapsesocial.com/papers/6aaf85cb190bdc86ace39b04 https://doi.org/10.1039/c6ra10450a

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Dipeptidyl peptidase‐4 inhibitors in the treatment of type 2 diabetes: a comparative reviewReview · 2010 · 526 citations
2Safety and Tolerability of Linagliptin in Patients With Type 2 Diabetes: A Comprehensive Pooled Analysis of 22 Placebo-controlled StudiesRCT · 2014 · 60 citations
3Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysisRCT · 2012 · 438 citations
4Pharmacokinetics of linagliptin in subjects with hepatic impairmentOriginal Research · 2012 · 77 citations
5Pharmacokinetic and pharmacodynamic evaluation of linagliptin in African American patients with type 2 diabetes mellitusEarly-Phase Clinical Trial · 2013 · 18 citations

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