Key result
Amniotic membrane patch during pericardiectomy results in no postoperative inflammation or effusion in one patient.
Why the study?
Inflammatory processes are central to constrictive pericarditis, but the pathophysiology remains largely unknown and treatment challenging.
Does the intraoperative application of an amniotic membrane patch during pericardiectomy reduce post-operative inflammation in a patient with constrictive pericarditis?
Case Report (n=1)
No
Does the intraoperative application of an amniotic membrane patch during pericardiectomy reduce post-operative inflammation in a patient with constrictive pericarditis?
The application of an amniotic membrane patch during pericardiectomy for constrictive pericarditis may reduce post-operative inflammation and edema, warranting further research.
Answers are grounded in this paper and cite their sources.
May reduce post-pericardiectomy inflammation; hypothesis-generating in one case, requiring prospective trials before adoption.
BACKGROUND: Since constrictive pericarditis is most often idiopathic and the pathophysiology remains largely unknown, both the diagnosis and the treatment can be challenging. However, by definition, inflammatory processes are central to this disease process. Amniotic membrane patches have been shown to possess anti-inflammatory properties and are believed to be immune privileged. Due to these properties, amniotic membrane patches were applied intraoperatively in a complicated patient presenting with constrictive pericarditis. CASE PRESENTATION: A patient with a history of multiple cardiac surgeries presented with marked fatigue, worsening dyspnea and sinus tachycardia. He was found to have constrictive physiology during cardiac catheterization, with cardiac MRI demonstrating hepatic vein dilatation, atrial enlargement and ventricular narrowing. After amniotic membrane patch treatment and pericardiectomy, post-operative cardiac MRI failed to demonstrate any appreciable pericardial effusion or inflammation, with no increased T2 signal that would suggest edema. CONCLUSIONS: Given the positive results seen in this complex patient, we suggest continued research into the beneficial properties of amniotic membrane patches in cardiac surgery.
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Marsh et al. (2017) conducted a case report in Constrictive pericarditis (n=1). Amniotic membrane patch was evaluated on Postoperative inflammation and pericardial effusion on MRI. Application of an amniotic membrane patch during pericardiectomy in a patient with constrictive pericarditis resulted in no appreciable postoperative inflammation or pericardial effusion on MRI at five weeks.
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