Therapeutic Effects ofAllium sativumon Lead-induced Biochemical changes in Soft tissues of Swiss Albino Mice

Allium sativum (Meaning pungent) belongs to the Alliaceae family and genus Allium, is generally known in the developing world for its characteristic fl avor, a medicinal plant and a source of vegetable oil.Besides, the plant is reported to have various biological activities including hypocholesterolemic, antiatherosclerotic, anticoagulant, antibacterial, antifungal, anti-diabetic, antitumor agent; used for treating various disease such as infl ammation, cardiovascular and liver diseases.The objective of this study is to investigate the therapeutic effects of Allium sativum on lead induced toxicity in mice.Chronic dose of lead (2 mg/Kg body weight, i.p.), showed signifi cant decrease in antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and the nonenzymatic antioxidant as glutathione (GSH) and total protein content in the liver, kidney and brain.This decrease was accompanied with signifi cant increase in lipid peroxidation and cholesterol level.Also, there were disturbances in the liver, kidney and brain functions manifested by signifi cant changes in their functional markers.Effi cacy of garlic to reduce tissue lead concentration was also evaluated.Mostly, all of the investigated parameters were restored nearly to the normal values after raw garlic extract treatment.In conclusion, garlic exerts its effects not only as an antioxidant but also as a sulfur donor.So, garlic has a promising role and it is worth to be considered as a natural chelating agent for lead intoxication.