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January 31, 2015Molecular ImprintingOpen Access

Magnetic surface imprinted hydrogel nanoparticles for specific and reversible stabilization of proteins

Yibin Liu Junqiu Zhai Jiantong Dong Meiping Zhao

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Abstract

In this work, we demonstrate the unique capability of surface imprinted hydrogels over magnetic nanoparticles (Fe3O4@MIP-NPs) for protection of enzyme proteins from denaturation induced by heat, UV irradiation, ultrasonication and addition of urea. Moreover, the Fe3O4@MIP-NPs successfully enabled rapid renaturation of heat-denatured proteins under mild conditions. These interesting properties of MIP nanoparticles offer useful tools for protection and renaturation of proteins in various applications.

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Liu et al. (2015) studied this question.

synapsesocial.com/papers/6aaf8bdfcf0423585676f48b https://doi.org/10.1515/molim-2015-0006

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