Key result
Dobutamine during dialysis is linked to fewer hypotensive episodes, higher LVEF, and fewer hospital admissions.
Why the study?
Intradialysis hypotension is a common problem in maintenance hemodialysis patients with poor left-ventricular function, and effective therapies are needed.
Does dobutamine infusion during dialysis reduce hypotensive episodes in maintenance hemodialysis patients with LVEF <40% and persistent hypotension?
Population
6 maintenance hemodialysis patients with LVEF <40% and frequent severe hypotension
Comparison
Dobutamine infusion during dialysis vs no dobutamine
Design
Observational case series
Authors
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May benefit low-LVEF hemodialysis patients; leaves open need for randomized confirmation before practice change.
Observational (n=6)
Does dobutamine infusion during dialysis reduce hypotensive episodes in maintenance hemodialysis patients with LVEF <40% and persistent hypotension?
In a small case series, dobutamine infusion during hemodialysis improved hemodynamics and reduced emergency admissions in patients with HFrEF and intradialytic hypotension.
Anand et al. (1999) conducted an observational in Intradialysis hypotension (n=6). Dobutamine infusion was evaluated on Number of hypotensive episodes. Dobutamine infusion during dialysis significantly reduced hypotensive episodes, increased left-ventricular ejection fraction, and decreased emergency hospital admissions.