A study of the amino-acid complexes formed by metals of Group II of the periodic classification

NUCLEIC ACIDS OF DEGENERATING NERVE 487 3. The lipid phosphorus changed little during the first 8 days and then decreased rapidly during the period 8-32 days after either nerve section or nerve crush.In the sectioned nerves the lipid phosphorus fell still further, whereas in the crushed nerves it had commenced to increase by 96 days and continued to increase throughout the period of regeneration.4. The concentration of total nucleic acid in- creased after either nerve section or nerve crush, reaching a maximum in 16 days.Thereafter the concentration of nucleic acid fell in both the sectioned and crushed nerves.After each type of operation the PNA increased more rapidly than the DNA, so that there was an increase in the PNA/DNA ratio.5. The PP fell throughout the whole course of the degeneration in the sectioned nerves.In the crushed nerves it had commenced to rise by 96 days, and by 250 days it approximated the concentration in the control nerves.6.The 'inositide phosphorus' followed a course similar to that of the lipid phosphorus.After either type of operation there was little change during the first 8 days, followed by a rapid fall during the period 8-32 days.In the sectioned nerves the 'inositide phosphorus' fell still further, whereas in the crushed nerves it had commenced to increase by 96 days and continued to rise during the entire period of study.7. The increase in the concentration of nucleic acid and the decrease in the concentration of lipid phosphorus and 'inositide phosphorus' still persisted 600 days after nerve crush.