Key result
Gene targeting of the renin-angiotensin system reveals its critical role in homeostasis and pathological states.
Why the study?
Disturbances in the renin-angiotensin system may be important in numerous pathological states, but major insights and questions remain from gene targeting studies.
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Design
Review of gene targeting studies on the renin-angiotensin system
Answers are grounded in this paper and cite their sources.
This review summarizes physiological insights and questions arising from genetic manipulation of the renin-angiotensin system.
The renin-angiotensin system is one of the most widely studied endocrine systems. It has an important role in the regulation of normal homeostasis, and disturbances in this system may be important in numerous pathological states. This review will focus on the major insights and important questions raised from gene targeting of this system.
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Stec et al. (2001) studied this question. Gene targeting of the renin-angiotensin system reveals major insights into its critical role in normal homeostasis regulation and its contribution to various pathological states.
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