Case-control study reveals no significant link between IL-4 gene VNTR polymorphism and type 2 diabetes, suggesting this variant does not influence disease risk.
Background and purpose: Diabetes is a prevalent condition affecting a significant portion of the population worldwide, with inflammation playing a crucial role in its development and progression.Interleukin-4 (IL-4), as an anti-inflammatory cytokine, has the potential to reduce inflammation.The aim of this study was to determine the association between IL-4 gene VNTR polymorphism in individuals with type 2 diabetes.Methods: This case-control study included 50 individuals with diabetes who presented to Alameh Behlol Hospital in Gonabad, and 50 healthy individuals in the control group.Participants were randomly selected and, upon meeting inclusion criteria, entered the study after providing informed consent.Two milliliters of blood were collected from each participant using EDTA-containing tubes.DNA extraction was performed using the salting-out method.The targeted DNA segment was amplified using appropriate primers, and electrophoresis was employed for identification. Results:The mean age of the study participants was 30.7 ± 9.8 years, with 50% being male.The results indicated no significant association between IL-4 gene VNTR polymorphism and the occurrence of type 2 diabetes (p > 0.05). Conclusion:In the studied population, there was no significant association between IL-4 gene VNTR polymorphism and type 2 diabetes.
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Nasrollahzadeh et al. (2023) studied this question.
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