Key result
LVEF ≥50% is linked to better overall survival vs LVEF <50% in hereditary ATTR-CM.
Why the study?
Hereditary transthyretin amyloid cardiomyopathy has heterogeneous clinical manifestations leading to misdiagnosis and poor prognosis, with limited data on Chinese patients.
Population
23 Chinese patients with hereditary ATTR-CM at Peking Union Medical College hospital
Design
Retrospective cohort study
Follow-up
Up to 60 months
Authors
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Preserved LVEF may inform prognosis discussions in Chinese hereditary ATTR-CM; extends prior observations but leaves open therapeutic implications.
Cohort (n=23)
No
p-value: p=0.045
Hereditary ATTR-CM in Chinese patients is characterized by a high prevalence of mixed phenotypes, delayed diagnosis, and poor overall survival, though patients with preserved LVEF have a better prognosis.
He et al. (2019) conducted a cohort in Hereditary transthyretin amyloid cardiomyopathy (ATTR-CM) (n=23). LVEF ≥50% vs. LVEF <50% was evaluated on Overall survival (p=0.045). LVEF ≥50% was associated with significantly better overall survival compared to LVEF <50% in Chinese patients with hereditary ATTR-CM (P=0.045).
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