The First Stereoselective Bifunctionalization of 4-Quinolones with Organometallics and N-Halosuccinimides to 2,3-trans Disubstituted Tetrahydroquinolones: Expected and Unexpected Results

This is the authors' abstract. We don't add key points for this paper.

All articles of this category The C-2-addition of organometallic reagents to 4-quinolones followed by reaction with N -halosuccinimides provides a short and diastereoselective entry for the preparation of 2,3- trans disubstituted tetrahydroquinolones. organolithium reagents - Grignard reagents - C-2 addition - halogenation - quinolones