Key result
Pluripotent cells combat viruses using RNA interference while differentiated somatic cells rely on interferon.
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Undergoing Antiviral SignalingThe ability of the RNAi pathway to combat virus infection is shared among many metazoans including plants and invertebrates.
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Pare et al. (2014) conducted a review in Viral infection in pluripotent vs differentiated cells. Pluripotent cells have an attenuated interferon-based antiviral response but can utilize RNA interference to combat viruses, whereas differentiated somatic cells rely primarily on the interferon response.
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