Key result
HDL-mediated macrophage cholesterol efflux capacity was not significantly associated with aneurysm growth rate or progression in patients with small/medium size abdominal aortic aneurysms.
Why the study?
The role of HDL-mediated macrophage cholesterol efflux in abdominal aortic aneurysm progression and growth prediction was unclear.
Does HDL-mediated macrophage cholesterol efflux capacity predict abdominal aortic aneurysm growth or the need for surgery?
Observational (n=158)
Does HDL-mediated macrophage cholesterol efflux capacity predict abdominal aortic aneurysm growth or the need for surgery?
Although HDL-mediated macrophage cholesterol efflux is impaired in large abdominal aortic aneurysms, it does not appear to drive or predict aneurysm progression.
Cholesterol efflux capacity should not guide surveillance in small/medium AAAs; leaves open its role in larger aneurysms or as a therapeutic target.
Recent studies have raised the possibility of a role for lipoproteins, including high-density lipoprotein cholesterol (HDLc), in abdominal aortic aneurysm (AAA). The study was conducted in plasmas from 39 large size AAA patients (aortic diameter > 50 mm), 81 small/medium size AAA patients (aortic diameter between 30 and 50 mm) and 38 control subjects (aortic diameter < 30 mm). We evaluated the potential of HDL-mediated macrophage cholesterol efflux (MCE) to predict AAA growth and/or the need for surgery. MCE was impaired in the large aortic diameter AAA group as compared with that in the small/medium size AAA group and the control group. However, no significant difference in HDL-mediated MCE capacity was observed in 3 different progression subgroups (classified according to growth rate < 1 mm per year, between 1 and 5 mm per year or >5 mm per year) in patients with small/medium size AAA. Moreover, no correlation was found between MCE capacity and the aneurysm growth rate. A multivariate Cox regression analysis revealed a significant association between lower MCE capacity with the need for surgery in all AAA patients. Nevertheless, the significance was lost when only small/medium size AAA patients were included. Our results suggest that MCE, a major HDL functional activity, is not involved in AAA progression.
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Canyelles et al. (2020) conducted an observational in Abdominal Aortic Aneurysm (AAA) (n=158). HDL-mediated macrophage cholesterol efflux (MCE) vs. Control subjects or higher MCE capacity was evaluated on AAA growth rate and/or the need for surgery. HDL-mediated macrophage cholesterol efflux capacity was not significantly associated with aneurysm growth rate or progression in patients with small/medium size abdominal aortic aneurysms.
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