Key result
Paclitaxel-coated stents for hepatic artery thrombosis fail to maintain long-term patency despite normal graft function.
Why the study?
Hepatic artery thrombosis is the most common vascular complication after orthotopic liver transplantation and requires effective treatment options.
Does percutaneous balloon angioplasty and paclitaxel-coated stent placement improve survival and graft function in patients with early-onset hepatic artery thrombosis after liver transplantation?
Case Report (n=3)
No
Does percutaneous balloon angioplasty and paclitaxel-coated stent placement improve survival and graft function in patients with early-onset hepatic artery thrombosis after liver transplantation?
Paclitaxel-coated stents for early-onset hepatic artery thrombosis after liver transplantation do not maintain long-term patency, although patients may still maintain normal graft function.
May support percutaneous stenting in select early HAT cases; leaves open efficacy and safety questions pending larger prospective studies.
Hepatic artery thrombosis (HAT) is the most common vascular complication of orthotopic liver transplantation (OLT) and constitutes a potential emergency during the postoperative period. Surgical revascularization and retransplantation are the treatments of choice for this condition. The aim of this report is to present long-term follow-up on survival and graft function of three patients with paclitaxel-coated hepatic artery stents placed percutaneously after earlyonset HAT. Three patients developed early onset HAT after cadaveric-donor OLT in a tertiary care center in Mexico. These patients were treated percutaneously with balloon angioplasty and paclitaxel-coated stents. After 24 months or more of follow-up, 2 patients present total occlusion of the stent and one patient, intra-stent stenosis; interestingly, all patients have normal graft function and excellent quality of life. In conclusion, although balloon angioplasty and stent placement may be a therapeutic option for suitable patients with early-onset HAT after OLT, longterm patency is unlikely even with the use of paclitaxel- coated materials.
No takes yet. Share an insight, caveat, or question.
Reyes-Corona et al. (2007) conducted a case report in Early-onset hepatic artery thrombosis after orthotopic liver transplantation (n=3). Percutaneous balloon angioplasty and paclitaxel-coated stents was evaluated on Long-term stent patency, survival, and graft function. Paclitaxel-coated stent placement for early-onset hepatic artery thrombosis after liver transplantation resulted in loss of long-term patency in all 3 patients, though graft function remained normal.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: