Nonneoplastic Lung Responses Induced in Experimental Animals by Exposure to Poorly Soluble Nonfibrous Particles

The intent of this article is to review the comparative nonneoplastic pathological responses (inflammation, fibrosis, and epithelial proliferation) of rats, hamsters, mice, and monkeys to low-toxicity dusts (TiO(2), carbon black, talc, coal-mine dust, and diesel particulate). The paucity of information on some of these comparisons and the important information on other dusts (e.g., silica) that illuminate this question have necessitated inclusion of a number of papers that go beyond these nontoxic dusts.