The oxo ester (8), from the thiazolium salt catalysed conjugate addition of (S)-citronellal to ethyl acrylate, has been used in a synthesis of the cytochalasa-1,18,21-trione (3). This reacts both regio- and stereo-selectively with methylmagnesium chloride to provide the cytochalasin H precursor (4).
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Sauter et al. (1989) studied this question.