The replacement of H2O by D2O as a solvent resulted in an appreciable increase in the binding constants (Kb) for complexes of native and modified cyclodextrins with such typical guests as p-nitrophenol, the p-nitrophenolate ion, Methyl Orange, phenolphthalein, and inorganic anions. The observed increase in Kb was attributed mainly to a solvent H/D isotope effect on hydrophobic and electrostatic interactions between the hosts and guests.
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Wang et al. (1994) studied this question.
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