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Using a two-beam interferometer and a high-pressure cell with transparent windows, we measured the solubility of crystals under high pressure in situ. This method enabled us to observe in situ the transitional process of equilibration with a small quantity of specimens. We applied this method to measure a pressure dependence of the solubility of NH4Cl in water and compared with the previous data obtained by other techniques. It was found that this method is precise and suitable to measure the solubility of rare and expensive materials such as proteins.
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Suzuki et al. (1998) studied this question.
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