Acute graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT) is a complex process that involves donor T cells and multiple cellular and cytokine effectors. Detailed knowledge of T-cell responses to minor histocompatibility (H) antigens is scant. In this issue Choi and
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James L.M. Ferrara (2002) studied this question.
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