Mortality Associated with the Use of Inappropriate Drugs According Beers Criteria: a Systematic Review

The aims of this systematic review are to identify and analyse the scientist literature available evidence about the use of potentially inappropriate medications, according to the Beers Criteria, that is associated with mortality in the elderly people. It have been made a search of publications in most traditional electronic databases among the scientific community (Pubmed / Medline, EMBASE and Web of Science) and it have been selected publications that obey the criteria of 'observational study', 'elderly' and 'Beers Criteria' and that they had as a result the mortality of the study population. After publications selection it proceeded to dump data by two researchers independently to avoid selection bias. The methodological quality of the selected studies was assessed by the checklist Newcastle-Ottawa. The final sample of this systematic review has been made up of 17 studies published in Pubmed and Embase databases majority, 8 of which make up the meta-analysis. In descriptive synthesis has been observed that most of the studies have a level of evidence IV (94'1%) with cohort delineation (94'1%) and non-probability sampling technique (70'6%).Data collection was prospective in 58'8% of cases, with a sample (n) greater than 1000 elderly (64'7%) and followed up for 6 to 12 months (52'9%).The meta-analysis involving 90.611 elders informed that users who take inappropriate drug according to the Beers Criteria had a higher relative risk for mortality outcome (RR = 1.11, 95% CI 1'01-1'22 P = 0'023), regardless of study stage, comorbidity presence, polypharmacy or type of inappropriate medication used.