All articles of this category Optically pure 1-butyne-3,4-diol has been obtained expediently in a satisfactory overall yield from 2,5-dihydrofuran on sequential epoxidation, nucleophilic cleavage, lipase-mediated resolution, and base-induced double elimination. lipase-mediated resolution - ( R )- and ( S )-1-butyne-3,4-diol - 2,5-dihydrofuran - double elimination - acetylene formation
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Yamada et al. (1995) studied this question.