A vacuole-formation substance, cereulide of Bncillus cereus, is an emetic toxin in animals.Both oral administration and intraperitoneal injection of cereuiide caused dose-dependent emesis in Suncus murinus, a new animal model of emesis.Vagotomy or a 5-HT, receptor antagonist completely abolished this emetic effect.Therefore, cereulide causes emesis through the 5-HT, receptor and stimulation of the vagus afferent.We also found that our purified cereulide caused swelling of mitochondria of HEp-2 cells.
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Agata et al. (1995) studied this question.
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