Key result
Higher cardiovascular health linked to reduced bidirectional risk between cancer and cardiometabolic diseases.
Why the study?
Bidirectional associations of cardiovascular disease, type 2 diabetes, and cancer exist, partly due to shared risk factors, but the role of cardiovascular health in these transitions is unclear.
Does higher cardiovascular health reduce the risk of bidirectional transitions between cardiovascular disease, type 2 diabetes, and cancer?
Cohort (n=339,968)
Does higher cardiovascular health reduce the risk of bidirectional transitions between cardiovascular disease, type 2 diabetes, and cancer?
Maintaining high cardiovascular health (Life's Essential 8) is associated with a reduced risk of developing subsequent cardiometabolic diseases or cancer among those with pre-existing conditions.
Answers are grounded in this paper and cite their sources.
High CVH was associated with lower bidirectional transition risks among CVD, T2D, and cancer; supports CVH optimization for multimorbidity prevention but leaves causal effects open.
BACKGROUND: There existed bidirectional associations of cardiovascular disease (CVD) and type 2 diabetes (T2D) with cancer, partly attributed to their shared risk factors. We aimed to explore the role of cardiovascular health (CVH) in bidirectional transitions between CVD, T2D, and cancer. METHODS: Based on the UK Biobank, we used 2 subcohorts: a disease-free cohort of 277 997 individuals without cancer, CVD, and T2D; and a disease survivor cohort consisting of 61 971 cases with cancer, CVD, and T2D at baseline. The CVH was assessed on the basis of Life's Essential 8 score. We conducted the multistate model and Cox proportional hazards model to explore the role of CVH in bidirectional transitions between CVD, T2D, and cancer in disease-free and disease survivor cohorts, respectively. RESULTS: for trend<0.001), particularly in the high CVH group. For disease survivor cohorts, per 10-point increase in CVH was associated with >10% lower cancer risk in CVD and T2D cases, and a 16% and 42% reduction in the risk of incident CVD and T2D among cancer survivors, respectively. CONCLUSIONS: High CVH was related to a decreased risk of bidirectional transitions between CVD, T2D, and cancer. This highlighted the significance of maintaining high CVH throughout the life span for the primary prevention of CVD, T2D, and cancer.
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Peng et al. (2025) conducted a cohort in Cardiovascular disease, type 2 diabetes, and cancer (n=339,968). Cardiovascular health (Life's Essential 8 score) vs. Lower cardiovascular health was evaluated on Bidirectional transitions between CVD, T2D, and cancer (p=<0.001). A 10-point increase in cardiovascular health score was associated with >10% lower cancer risk in CVD and T2D cases, and a 16% and 42% reduction in incident CVD and T2D among cancer survivors.
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