In this issue, de Kort and colleagues report a thorough analysis of acute antibody‐mediated rejection (acute AMR) in pancreas allografts. The study is an important practical reference for those working in the field of pancreas transplantation, and adds considerably to the number of published cases. The first message is that all grafts lost to rejection had C4d deposition, confirming the importance of antibody‐mediated rejection in pancreas, as documented in the kidney. The second message is that the combination of C4d and donor HLA‐specific antibody (DSA) has greater prognostic significance than either alone.
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Robert B. Colvin (2010) studied this question.
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