In the course of screening for new bioactive compounds, we have isolated two antibiotics from the fermentation broth of Streptomyces sp.TC 1190 and were designated TMC-135A and B. Spectroscopic analyses revealed that TMC-135s were new members of triene-ansamycins, closely related to thiazinotrienomycins and cytotrienins1 ^.This paper briefly describes the taxonomy, isolation, physico-chemical properties, structure elucidation and biological activity ofTMC-135A and B. The producing strain TC 1190 was isolated from a soil sample.The substrate mycelium developed well and branched irregularly.Each spore chain, which was spiral type, had 20 to 50 or more spores per chain.The spores were cylindrical, with size of 0.5-0.8X0.6-0.9^m, and the surface was rugose.Fragmentation of substrate pp.724-727 mycelium, sporangium, or motile spore was not observed.Analysis of the whole-cell hydrolysates of the strain showed the presence of LL-diaminopimelic acid.On the basis of
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NISHIO et al. (2000) studied this question.