Regulation of Protein Tyrosine Kinase Activation by the T-cell Antigen Receptor Chain

This is the authors' abstract. We don't add key points for this paper.

Resting antigen-specific T lymphocytes in the G0 stage of the cell cycle encounter antigenic peptides bound to major histocompatibility complex (MHC) molecules on the surfaces of antigen-presenting cells. These T cells are activated to proliferate and exhibit a variety of differentiated functions. This complex cellular interaction involves a large number of plasma membrane molecules on the T cell and the antigen presenting cell. However, the T-cell antigen receptor (TCR) must play a central role in directing the initiation of antigen-specific responses.