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July 28, 2006Nucleosides Nucleotides & Nucleic Acids

Synthesis and Antiviral Activity of Some C 2 -, C 4 -, and C 6 -Substituted Pyrazolo[3,4-D]Pyrimidine Acyclonucleosides with the Alkylating Chains of ACV, HBG, and ISO-DHPG

Omar Moukha‐Chafiq Mohamed Labd Taha Hassan Bihi Lazrek Jean‐Jacques Vasseur Erik De Clercq

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Abstract

A useful route to obtain trisubstituted pyrazolo[3,4-d]pyrimidines 14-17 is described. Those later were coupled with the alkylating agents 18-20 as in ACV, HBG, and iso-DHPG to give, after deprotection, the desired acylonucleosides 33-44. Almost all of the new compounds were evaluated for their inhibitory effects against the replication of various DNA viruses in culture.

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Moukha‐Chafiq et al. (2006) studied this question.

synapsesocial.com/papers/6ab084b439c05b4110852f1a https://doi.org/10.1080/15257770600793802

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