Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium( iv )/naringin complex

Gonzalo Restrepo-Guerrero; Angel L. Huamani; Alexandra Velásquez Bravo; Pablo J. González; Luciana Naso; Evelina G. Ferrer; Patricia A.M. Williams

doi:10.1039/d4nj00655k

January 1, 2024New Journal of ChemistryOpen Access

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium( iv )/naringin complex

View Full Paper

Ask AI

Bookmark

Share

Key Points

To evaluate how the secondary ligand phenanthroline influences the antioxidant, pro-oxidant, and cytotoxic activities of oxidovanadium(IV)/naringin complexes.
Synthesized and characterized oxidovanadium(IV) complexes coordinated with naringin and substituted with phenanthroline.
Evaluated π-electron delocalization, lipophilicity, intracellular vanadium uptake, and cell toxicity profiles.
Substituting phenanthroline into the complex promoted π-electronic delocalization, resulting in improved antioxidant performance.
The lipophilic nature of phenanthroline significantly increased intracellular vanadium accumulation, driving enhanced pro-oxidant generation and anticancer cytotoxic actions.

Implication

Experimental analysis demonstrates that incorporating phenanthroline into oxidovanadium-naringin complexes enhances cellular uptake and cytotoxicity in cancer cells, highlighting potential...

Abstract

Replacement of phen in [VO(Narg) 2 ] induces greater π electronic delocalization, thus improving antioxidant action. However, due to its lipophilic character, cellular uptake of V is increased, leading to enhanced pro-oxidant and anticancer effects.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Restrepo-Guerrero et al. (2024) studied this question.

synapsesocial.com/papers/6ab0865f527d7ac94f3d50a7 https://doi.org/10.1039/d4nj00655k

View Full Paper

Ask AI

Bookmark

Share

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium( iv )/naringin complex

Key Points

Implication

Abstract

Discussion

Cite This Study

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium( iv )/naringin complex

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading