The IgG subclass of 659 IgG myeloma proteins was determined with subclass‐specific antisera in agar precipitation technique. The following distribution was found: IgG1, 80%; IgG2, 10%; IgG3, 6.4%; IgG4, 3.6%. In addition, the light chain distribution among myeloma proteins of the subclasses was studied. The K/L ratio of the IgG1 proteins was 1.7; IgG2, 2.05; IgG3, 2.2; and IgG4, 3.0. These ratios did not differ significantly. In 9 sera with IgG double M‐components, the combination IgG1‐IgG4 was found to be predominant.
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Skvaril et al. (1972) studied this question.
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