Key result
Influenza A nw strain forms smaller plaques than nws strain due to delayed viral release.
Why the study?
The cause of small plaque size in the recombinant nw strain of influenza A virus compared to the neurotropic nws strain was unclear.
Population
BHK21 cells infected with influenza A viruses nws and recombinant nw
Comparison
Infection with recombinant nw strain vs neurotropic nws strain
Design
Preclinical study
Authors
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Delayed virus formation/release explains small NW plaques in vitro; leaves open relevance to influenza fitness or pathogenesis.
The smaller plaque size of the nw influenza A strain is caused by delayed maturation and release of infectious virus, along with the production of noninfectious haemagglutinin.
Samuel T. Milliken (1967) studied Influenza A virus infection (in vitro). nw strain of Influenza A virus vs. nws strain of Influenza A virus was evaluated on Plaque size and rate of viral increase. The small plaque size of the nw strain of Influenza A virus compared to the nws strain is caused by a delay in the formation and release of infectious virus.
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