A highly practical asymmetric synthesis of oseltamivir has been accomplished in 18 steps from d-mannitol without any chromatographic purification, which features intramolecular aldol condensation of dialdehyde with a 3-pentyl ether moiety in constructing densely functionalized cyclohexene ring of oseltamivir.
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Mandai et al. (2009) studied this question.
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