Comparative Tests of the Thiosulphate and Creatinine Clearance in Rabbits and Cats

Summary. In rabbits, simultaneous determinations have demonstrated identity between creatinine and thiosulphate clearances in 9 tests though for two other animals the values for the thiosulphate clearance were slightly lower than for the creatinine clearance. In cats, on the other hand, the thiosulphate clearance when the plasma thiosulphate concentrations are low may have a value twice as high as that of the creatinine clearance,.whereas with a rising plasma thiosulphate concentration the difference approaches 0. Presumably the explanation is that the cat kidney can secrete thiosulphate.