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January 16, 2018Blood

Hif-1α and Hif-2α regulate hemogenic endothelium and hematopoietic stem cell formation in zebrafish

Claudia Gerri Michele Marass Andrea Rossi Didier Y. R. Stainier

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Abstract

morphant EHT phenotype, suggesting that Notch signaling functions downstream of the Hif pathway during HSC formation. Altogether, our data provide genetic evidence that both Hif-1α and Hif-2α regulate EHT upstream of Notch signaling.

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Gerri et al. (2018) studied this question.

synapsesocial.com/papers/6ab093b64b0be1a99e3f2f99 https://doi.org/10.1182/blood-2017-07-797795

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