Multiple studies have investigated the efficacy of intrathecal opioids, particularly sufentanil, in laboring parturients.However, until the important pharmacological indices of the 50% and 95% effective doses (ED50 and ED95, respectively) are defined, reliable comparative studies among drugs at equipotent doses cannot be performed. This study was performed to establish the dose-response relationship of intrathecal sufentanil analgesia in labor. Sixty parturients presenting in active labor received intrathecal sufentanil 2.5 (n = 10), 5.0 (n = 10), 7.5 (n = 10), 10.0 (n = 10), 12.5 (n = 10), or 15.0 (n = 10) micro g in a blind, randomized fashion. Patient 100-mm visual analog pain scale (VAS) scores, fetal heart rate (FHR), blood pressure, and heart rate were recorded at 0, 1, 5, 10, 15, 20, 25, and 30 min after administration of sufentanil and then again when the patient requested additional analgesia. Absolute VAS
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Herman et al. (1997) studied this question.