The acid-catalyzed addition of water to the vinyl ether double bond of aflatoxin Bx was investigated. The hemiacetal produced was biologically inactive to the chick embryo and to tissue cultures at respective concentrations 80 and 50 times the minimum lethal dose of aflatoxin B1 The structure of the hemiacetal was established and found to be identical to the hemiacetal reported as an intermediate in the total synthesis of racemic aflatoxin B1
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Borland et al. (1968) studied this question.