All articles of this category The tandem nucleophilic addition-aldol reaction of methyl propynoate, iodide ion, and aldehydes or ketones in the presence of ZrCl 4 as the catalyst gave methyl 3-iodo-2-(1-hydroxyalkyl)prop-2-enoates with high Z selectivity, which were further transformed to α -( Z )-iodomethylene- β -lactones in good yield. propynoate - tandem nucleophilic addition-aldol reaction - Z selectivity - ( Z )-3-iodo-2-(1-hydroxyalkyl)prop-2-enoates - α -( Z )-iodomethylene- β -lactones
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Zhang et al. (1996) studied this question.