Statistical Methods to Evaluate Health Effects Associated with Major Sources of Air Pollution: A Case-Study of Breathing Patterns During Exposure to Concentrated Boston Air particles

Summary We conduct a case-study evaluating the source-specific effects of particulate matter on respiratory function. Using a structural equation approach, we assess the effect of different receptor models on the estimated source-specific effects for univariate respiratory response. Furthermore, we extend the structural equation model by placing a factor analysis model on the response to represent the measured respiratory responses in terms of underlying respiratory patterns. We estimate the particulate matter source-specific effects on respiratory rate, accentuated normal breathing and airway irritation and find a strong increase in airway irritation that is associated with exposure to motor vehicle particulate matter.