Answers are grounded in this paper and cite their sources.
[reaction: see text] Regioselective control of glycosylation of purines at N9 (versus N7) has been a continuing challenge. We now report Lewis acid catalyzed regiospecific glycosylations of 6-(2-alkylimidazol-1-yl)purines at N9. The 6-(2-alkyl)imidazole moiety also functions as a versatile leaving group that can be replaced by nucleophiles (S(N)Ar) and aryl groups (Suzuki cross-coupling).
No takes yet. Share an insight, caveat, or question.
Zhong et al. (2005) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: