Key result
Ticagrelor demonstrates antibacterial activity against drug-resistant Gram-positive strains but not Gram-negative bacteria.
Why the study?
The increasing deaths caused by drug-resistant bacteria create a need to develop new antimicrobial agents, and ticagrelor has been reported to have promising antibacterial properties.
Does ticagrelor have antibacterial properties against Gram-positive and Gram-negative bacteria?
Does ticagrelor have antibacterial properties against Gram-positive and Gram-negative bacteria?
Ticagrelor, an antiplatelet agent, shows potential as a novel antimicrobial agent specifically against Gram-positive bacteria.
Ticagrelor may warrant repurposing studies for resistant Gram-positive infections; current Level 5 evidence leaves open any clinical role.
The number of deaths caused by drug-resistant bacteria is expected to increase in the future, and there is a need to develop new antimicrobial agents. Recently, the antiplatelet drug ticagrelor has been reported to have promising antibacterial properties. The purpose of this review is to analyze articles and case reports that describe the antimicrobial action of ticagrelor. Ticagrelor was found to have antibacterial reactions against Gram-positive bacteria, including drug-resistant and spore-forming bacteria, while no effect was observed against Gram-negative bacteria. In this paper we discuss a new potential antimicrobial agent, ticagrelor.
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Ueda et al. (2023) conducted a review in Bacterial infections. Ticagrelor was evaluated. Ticagrelor demonstrated antibacterial activity against Gram-positive bacteria, including drug-resistant strains, but showed no effect against Gram-negative bacteria.
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