Ligand‐Dependent Upregulation of Ribosomal Shunting

A new response: A new type of hybridization switch-free ON-eRS (eukaryotic upregulating riboswitch) activates ribosomal shunting in response to a ligand. Whereas the ribosome that has finished sORF translation scans the 5′-side strand of the aptamer and stops at the rigid stem in the absence of the ligand, it shunts over the stem bearing the aptamer–ligand complex and then reinitiates translation of dORF in the presence of the ligand.