Key result
Living in Newfoundland and Labrador is linked to ~52% higher HDL dyslipidemia prevalence vs other Canadians.
Why the study?
Newfoundland and Labrador has the highest prevalence of cardiovascular disease in Canada, but the prevalence of dyslipidemia compared to the rest of Canada was unclear.
Does the prevalence of dyslipidemia differ between Newfoundland and Labrador and the rest of Canada?
Cross-Sectional (n=128,825)
Yes
Does the prevalence of dyslipidemia differ between Newfoundland and Labrador and the rest of Canada?
Odds Ratio: 1.52 (95% CI 1.44–1.6)
Absolute Event Rate: 38% vs 27%
p-value: p=<0.0001
The population of Newfoundland and Labrador has a significantly higher prevalence of dyslipidemia and worse lipid profiles compared to the rest of Canada, which may contribute to their higher rates of cardiovascular disease.
May underlie higher regional CVD rates; hypothesis-generating and requires prospective studies before practice implications.
INTRODUCTION: Newfoundland and Labrador (NL) has the highest prevalence of cardiovascular disease (CVD) in Canada. Dyslipidemia is a risk factor for CVD. This study compares the prevalence of dyslipidemia in the NL population with the rest of Canada. METHODS: A cross-sectional study, using data from the Canadian Primary Care Sentinel Surveillance Network (CPCSSN), was undertaken. The study population included adults, excluding pregnant women, aged 20 years and older. Canadian guidelines were used for classifying dyslipidemia. Univariate and multivariate analyses were conducted to compare the lipid levels and prevalence of dyslipidemia between NL and the rest of Canada. RESULTS: About 128,825 individuals (NL: 7,772; rest of Canada: 121,053) were identified with a mean age of 59 years (55% females). Mean levels of total cholesterol (4.96 vs. 4.93, p = 0.03), low-density lipoprotein (LDL) (3.00 vs. 2.90 mmol/L, p < 0.0001), triglyceride (1.47 vs. 1.41 mmol/L, p < 0.0001), and high-density lipoprotein (HDL) (1.29 vs. 1.39 mmol/L, p < 0.0001) were significantly different in NL compared to the rest of Canada. Dyslipidemias of LDL (29 vs. 25% p < 0.0001), HDL (38 vs. 27%, p < 0.0001), and triglyceride (29 vs. 26%, p < 0.0001) were significantly more common in NL. After adjustment for confounding variables, NL inhabitants were more likely to have dyslipidemia of total cholesterol (OR: 1.16, 95% CI: 1.10-1.23, p < 0.0001), HDL (OR: 1.52, 95% CI: 1.44-1.60, p < 0.0001), LDL (OR: 1.38, 95% CI: 1.30-1.46, p < 0.0001), and ratio (OR: 1.53, 95% CI: 1.42-1.60, p < 0.0001). CONCLUSION: The NL population has a significantly higher rate of dyslipidemia compared to the rest of Canada, and the mean levels of all lipid components are worse in NL. Distinct cultural and genetic features of the NL population may explain this, accounting for a higher rate of CVD in NL.
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Asghari et al. (2015) conducted a cross-sectional in Dyslipidemia (n=128,825). Living in Newfoundland and Labrador vs. Living in the rest of Canada was evaluated on HDL dyslipidemia (OR 1.52, 95% CI 1.44-1.60, p=<0.0001). Living in Newfoundland and Labrador was associated with a significantly higher prevalence of HDL dyslipidemia compared to the rest of Canada (OR 1.52).
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