Key result
Higher pleural fluid IFN-γ levels linked to developing residual pleural thickening ≥ 10 mm.
Why the study?
Predictive factors for the development of residual pleural thickening in patients with tuberculous pleurisy were not well identified.
Can baseline pleural fluid IFN-γ levels predict the development of residual pleural thickening in patients with tuberculous pleurisy?
Cohort (n=31)
No
Can baseline pleural fluid IFN-γ levels predict the development of residual pleural thickening in patients with tuberculous pleurisy?
Higher baseline pleural fluid IFN-γ levels may help predict the development of significant residual pleural thickening (≥ 10 mm) in patients with tuberculous pleurisy.
Higher pleural IFN-γ associates with RPT ≥10 mm; leaves open its predictive value or role in preventive strategies for tuberculous pleurisy.
BACKGROUND: The aim of our study was to identify predictive factors for the development of residual pleural thickening (RPT) in patients with tuberculous pleurisy (TP). METHODS: A retrospective study of patients with pleural tuberculosis. The clinical and radiological characteristics, and measurements of microbiological and biochemical parameters or markers such as adenosine deaminase (ADA), interferon-gamma (IFN-gamma) and vascular endothelial growth factor (VEGF) in pleural fluid were studied. RESULTS: Thirty one patients (24 male and 7 female) with a mean age of 55.9 years were studied. There were 25 (80.6%) patients with RPT > 2 mm and 6 (19.4%) patients without RPT. Ten patients (32.2%) had RPT > or = 10 mm. The rate of pleural thickening was less in small effusions (p<0.05). IFN-gamma was higher in patients with RPT > or = 10 mm (p < 0.05) in comparison with those with RPT < 10 mm. CONCLUSIONS: Pleural fluid IFN-gamma may deserve further investigation in order to build up preventive and therapeutic strategies against RPT and its clinical complications.
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Gerogianni et al. (2016) conducted a cohort in Tuberculous pleurisy (n=31). Pleural fluid IFN-γ levels vs. Patients with residual pleural thickening < 10 mm was evaluated on Development of residual pleural thickening (RPT) ≥ 10 mm (p=<0.05). Pleural fluid IFN-γ levels were significantly higher in patients who developed residual pleural thickening ≥ 10 mm compared to those with thickening < 10 mm (36.9 vs 23.7 UI/ml, p < 0.05).
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