Key result
Multidisciplinary treatment cures a man with mediastinal teratoma transformed into angiosarcoma.
Why the study?
Complete resection is essential for treating teratoma with malignant transformation, but metastatic cases are difficult to cure, necessitating exploration of multidisciplinary treatment approaches.
Case Report (n=1)
Multidisciplinary treatment based on histopathology may cure teratoma with malignant transformation even when complete resection is difficult.
Answers are grounded in this paper and cite their sources.
Multidisciplinary treatment achieved cure despite bone metastases in this rare case; leaves open whether this approach generalizes to similar mediastinal teratomas with malignant transformation.
Introduction: Complete resection is essential for the treatment of teratoma with malignant transformation, and if metastasis occurs, it will be difficult to cure. We report a case of primary mediastinal teratoma with differentiation into angiosarcoma that caused bone metastases but was cured by multidisciplinary treatment. Case presentation: A 31-year-old man with a primary mediastinal germ cell tumor underwent primary chemotherapy followed by post-chemotherapy resection, with angiosarcoma due to malignant transformation found in the surgical specimen. Femoral diaphyseal metastasis was manifested, and he underwent femur curettage followed by radiation therapy of 60 Gy in parallel with 4 cycles of chemotherapy combining gemcitabine and docetaxel. Although thoracic vertebral bone metastasis emerged 5 months after treatment, intensity-modulated radiation therapy was successful, and metastatic lesions have remained shrunken for 39 months after treatment. Conclusion: Even if complete resection is difficult, teratoma with malignant transformation may be cured by multidisciplinary treatment based on histopathology.
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Tani et al. (2022) conducted a case report in Primary mediastinal teratoma with differentiation into angiosarcoma (n=1). Multidisciplinary treatment (chemotherapy, resection, radiation therapy) was evaluated on Tumor shrinkage and cure. Multidisciplinary treatment including chemotherapy, surgery, and radiation therapy successfully cured a 31-year-old man with mediastinal teratoma with malignant transformation into angiosarcoma.
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