Sickle Cell Anemia Terminating in Acute Myeloblastic Leukemia

Case Reports1 October 1953SICKLE CELL ANEMIA TERMINATING IN ACUTE MYELOBLASTIC LEUKEMIAALBERT G. GOLDIN, M.D., KARL C. KELTY, M.D., MARION F. BEARD, M.D., F.A.C.P.ALBERT G. GOLDIN, M.D., KARL C. KELTY, M.D., MARION F. BEARD, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-4-920 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Herrick's description of sickle cell anemia in 19101 the literature on this disease has been abundant, with the result that its natural course is fairly well documented. Termination ordinarily occurs before middle age, death usually resulting from intercurrent infections, sickle cell crises, cardiac failure, or hemorrhage or infarction of the brain, as well as from transfusion reactions incident to therapy.2, 3The finding of leukemoid reaction is not uncommon in various hemolytic anemias,4, 5including sickle cell anemia. The difficulty in differentiating some leukemoid reactions from acute leukemia has been pointed out by nearly all writers on the subject....Bibliography1. Herrick JB: Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia, Arch. Int. Med. 6: 517-521, 1910. CrossrefGoogle Scholar2. GrahamMcCarty GSSH: Sickle cell (meniscocytic) anemia, South. M. J. 23: 598-607, 1930. CrossrefGoogle Scholar3. Henderson AB: Sickle cell anemia, clinical study of fifty-four cases, Am. J. Med. 9: 757-765, 1950. CrossrefMedlineGoogle Scholar4. HeckHall FJBE: Leukemoid reactions of the myeloid type, J. A. M. A. 112: 95-101, 1939. CrossrefGoogle Scholar5. HillDuncan JMCN: Leukemoid reactions, Am. J. M. Sc. 201: 847-857, 1941. CrossrefGoogle Scholar6. Wintrobe MM: Clinical hematology, 3rd Ed., 1951, Lea & Febiger, Philadelphia, pp. 853-854. Google Scholar6. (a) Ibid: p. 834. Google Scholar7. Krumbhaar EB: Leukemoid blood pictures in various clinical conditions, Am. J. M. Sc. 172: 519-533, 1926. CrossrefGoogle Scholar8. DowneyMajorNoble HSGJF: Leukemoid blood pictures of the myeloid type, Folia haemat. 41: 493-511, 1930. Google Scholar9. Leitner SJ: Bone marrow biopsy. Hematology in the light of sternal puncture, 1949, Grune & Stratton, New York, pp. 234-243. Google Scholar10. Custer RP: An atlas of the blood and bone marrow, 1949, W. B. Saunders Co., Philadelphia, pp. 188-197. Google Scholar11. KatoCardozo KWW: Hodgkin's disease with terminal eosinophilia occurring in a Negro child with sicklemia, J. Pediat. 12: 165-175, 1938. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Louisville, Kentucky*Received for publication April 15, 1953.From the Department of Medicine and Division of Hematology, Louisville General Hospital, Louisville, Kentucky. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAbsence of hydroxyurea‐induced mutational effects supports higher utilisation for the treatment of sickle cell anaemiaCase Series and Review of Hematological and Non-Hematological Malignancies in Aging Patients with Sickle Cell Disease in the Hydroxyurea EraCombination of Haemoglobinopathy and Haemopathy —(Adult T-Cell Lymphoma/Leukemia and Sickle Cell Disease: A Rare Case of Disease Observed in the Adult Referral Center of Sickle Cell Disease (CRD-A) in MartiniqueMalignancy in patients with sickle cell disease9p− in a girl with acute lymphocytic leukemia and sickle cell diseaseHematologic malignancy in sickle cell disease: Report of four cases and review of the literatureBone-Marrow Transplantation in a Patient with Sickle-Cell AnemiaSickling Syndromes in ChildrenFrequency and Prognosis of Coexisting Sickle Cell Disease and Acute Leukemia in Children 1 October 1953Volume 39, Issue 4Page: 920-928KeywordsAnemiaBrainHeart failureHematology and oncologyHemolytic anemiaHemorrhageHospital medicineInfarctionLeukemoidSickle cell disease ePublished: 1 December 2008 Issue Published: 1 October 1953 PDF downloadLoading ...