Prevalence of Co-existing Endometrial Carcinoma in Patients with Preoperative Diagnosis of Endometrial Hyperplasia

Endometrial hyperplasia, is defined as irregular proliferation of endo metrial glands and an increase at glands/stroma.By World Health Organization (WHO) in 1994, endometrial hyperplasia is divided into four groups as simple hyperplasia without atypia, complex hyperplasia without atypia, simple atypical hyperplasia and complex atypical hyperplasia and there is particulary strong relationship with atypical endometrial hyperplasia and endometrial cancer.Therefore, due to the high risks of endometrial cancer associated with postmenopausal atypical hyperplasia hysterectomy is recommended [1].But the 1994 criterias of WHO are quite subjective and especially lead to inconsistency in distinction of atypical endometrial hyperplasia and endometrial cancer.The concept of endometrial intraepithelial neoplasia have been proposed in recent years.Therefore, investiga tions need to be done more carefully in terms of the risks of endometrial cancer associated with endometrial hyperplasia [2].Endometrial hyperplasia usually develop as a result of excess estrogen unmet with progesterone.However, histologically simple hyperplasia without atypia is similar to normal proliferative endometrium while complex atypical hyperplasia is similar to welldifferentiated endometrioid adenocarcinoma.The rates of cancer accompanying with endometrial hyperplasia vary between 15-54% at many studies [3].In this study, patients diagnosed with endometrial hyperplasia and had hysterectomy, determination of the incidence of endometrial cancer accompanying postoperatively and clinical parameters associated with cancer are aimed. Obstetrics and Gynecology SectionPrevalence of Co-existing Endometrial Carcinoma in Patients with Preoperative Diagnosis of Endometrial Hyperplasia ABStrAct Introduction: Endometrial hyperplasia has been associated with the presence of concomitant endometrial carcinoma.In this study, patients who were diagnosed with endometrial hyperplasia and had hysterectomy, determination of the incidence of endometrial cancer accompanying postoperatively and clinical parameters associated with cancer are aimed. Materials and Methods:Endometrial biopsies were taken from patients for various reasons and among them 158 patients diagnosed with endometrial hyperplasia from pathologic examination results were retrospectively evaluated.All of the patient's age, parity, weight, transvaginal ultrasound measured by endometrial thickness, concomitant systemic disease (diabetes, hypertension, hypothyroidism), tamoxifen use, hormone use and whether in reproductive age or menopause were all questioned.Patients who applied with endometrial cancer, their cervical stromal involvement, lymph node involvement, cytology positivity and omental metastases were examined.Patients were classified according to their stage and grade.Patients who had intraoperative frozen were re-evaluated.results: Fifteen cases with preoperative endometrial hyperplasia diagnosed with endometrial cancer postoper atively, 2 cases had