Answers are grounded in this paper and cite their sources.
Hypoxic microenvironment is clinically associated with metastasis and poor prognosis of numerous cancers. Previous studies have shown that many protein-coding genes and microRNAs are regulated upon hypoxia and involved in the progression of cancer. However, the roles of lncRNAs in the hypoxia-responsive gene networks and how lncRNA-related signaling network regulates hypoxia induced tumor metastasis is still not clear.
No takes yet. Share an insight, caveat, or question.
Zhao et al. (2020) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: